Intolerance to Hexamethonium Bromide

The hemodynamic effects of hexamethonium bromide in the dog, with special reference to splanchnic pooling.

Regulation of blood pressure levels by hexamethonium bromide and mechanical devices.

Probably the first studies of the pharmacology of quaternary ammonium compounds were made by Crum-Brown and Fraser in 1868. Burn and Dale (1915) found that, unlike nicotine, tetraethyl-ammonium chloride blocked autonomic ganglia without noticeable initial stimulation. Barlow and Ing (1948a and b), Paton and Zaimis (1948a and b), and Balaban et al. (1949) studied the properties of some chemical ...

Effects of TEAC and hexamethonium bromide on the intestinal movements of dog.

It is well known that the action of a drug on the intestinal movements in a particular species of animal depends on its functional autonomic innervation. In the present studies T EAC and Ca have been found to increase the rhythmic movements of the adult mongrel dog's intestine (in situ). The gut was subjected to vigourous circular contracractions but without the propulsive motility. These actio...

Inotropic action of hexamethonium.

The positive inotropic action of hexainethoniuin in hypodynamic and freshly prepared papillary muscles of the cat and the hypodynamic heart-lung preparation of the dog has been demonstrated. Within certain limits, there exists a proportionality between the concentration of hexamethonium and the magnitude of the inotropic response. In both preparations results have been obtained which indicate t...

Hexamethonium and glaucoma.

THIS investigation was undertaken in an endeavour to decide if the methonium ganglion blocking compounds could be administered to cases of vascular hypertension who were known to be suffering from glaucoma, or to similar vascular hypertensive cases of a glaucomatous disposition although this might not be known, without the danger of subsequent sequelae such as an increase in intra-ocular pressu...